Alleviation of Acute Poisoning of Organophosphates in Humans-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS ANATOMY PHYSIOLOGY & BIOCHEMISTRY INTERNATIONAL JOURNAL Organophosphates (OPs) are used as pesticides and developed as warfare nerve agents. Exposure to an organophosphate could be lethal resulting in death due to respiratory failure. The mechanism of organophosphate poisoning includes inhibition of the acetyl cholinesterase (AChE) via phosphorylation of the hydroxyl group of serine present at the active site of the enzyme. The inhibition of acetyl cholinesterase (AChE) results in the accumulation of acetylcholine (ACh) at cholinergic receptor sites, producing continuous stimulation throughout the nervous systems. Several therapeutic agents have been developed and used in the treatment of poisoning with OPs. For example, pyridiniumoximes have been developed as therapeutic agents for the treatment of poisoning by OPs. The mode of action of pyridiniumoximes is by the reactivation of inhibited acetyl cholinesterase. However, the u...